Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases
نویسندگان
چکیده
Fig. 1. Peripheral blood (PB) smear and bone marrow (BM) aspirate findings of first case (A, B) and second case (C, D). (A) Eosinophilia (13.0×10/L) was observed in the PB (Wright-Giemsa, ×1,000). (B) Dysplastic eosinophils (sparse and mixed granules) were increased in the BM aspirate (Wright-Giemsa, ×1,000). (C) Eosinophilia (55.316×10/L) was observed in the PB (Wright-Giemsa, ×1,000). (D) The BM section was packed with eosinophils (hematoxylin-eosin, ×400). Blood 1997;90:1192-9. 9. Mitelman F, Johansson B, Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. Bethesda, MD: National Cancer Institute, 2013. (Assessed May 20, 2014, at http://cgap.nci.nih.gov/Chromosomes/Mitelman)
منابع مشابه
Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Table 1. Summary of Korean cases of chronic eosinophilic leukemia with FIP1L1-PDGFRA rearran...
متن کاملA case of histoplasmosis in a patient with MDS/MPN-U
REFERENCES 1. Shin SY, Jung CW, Choi DC, Lee BJ, Kim HJ, Kim SH. Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases. Blood Res 2015;50:58-61. 2. Jeung YJ, Lee JY, Lee GY, Oh MJ, Lee BJ, Choi DC. A case of idiopathic hypereosinophilic syndrome presenting with nocturia and dyspnea. Korean J Asthma Allergy Clin Immunol 2010;30:241-5. 3. ...
متن کاملMyeloproliferative Neoplasm with FIP1L1-PDGFRA Fusion Presenting as Extramedullary Acute Myeloid Leukemia (Myeloid Sarcoma) in a Lymph Node
Since its discovery 10 years ago, the FIP1L1-PDGFRA mutation has been associated with a wide spectrum of hematopoietic neoplasms which range from T-lymphoblastic leukemia/lymphoma, chronic eosinophilic leukemia, chronic myeloid leukemia, acute myeloid leukemia, myeloid sarcoma and systemic mastocytosis. Common between these neoplasms was eosinophila and sensitivity to imatinib and other tyrosin...
متن کاملChronic eosinophilic leukemia with FIP1L1-PDGFRA transcripts after occupational and therapeutic exposure to radiation
We present for the first time a 40-year-old male patient with a 20 year history of occupational exposure to radiation as a nuclear power plant worker, who developed FIP1L1-PDGFRA-positive chronic eosinophilic leukemia 27 months after radiotherapy for testicular seminoma. After an one-year history of dry cough, itching and night sweats, the patient presented with an elevated leukocyte count with...
متن کاملThe EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
We recently identified the chimeric kinase FIP1L1-platelet-derived growth factor receptor alpha (PDGFRalpha) as a cause of the hypereosinophilic syndrome and of chronic eosinophilic leukemia. To investigate the role of FIP1L1-PDGFRA in the pathogenesis of acute leukemia, we screened 87 leukemia cell lines for the presence of FIP1L1-PDGFRA. One cell line, EOL-1, expressed the FIP1L1-PDGFRA fusio...
متن کامل